A method was developed for the determination of migration of 5 ethanolamine compounds in food contact materials by liquid chromatography-tandem mass spectrometry（LC-MS/MS）.Samples were soaked with five food simulants（water，4% acetic acid，10% ethanol，50% ethanol，95% ethanol）.4% acetic acid soaking solution was dried out with nitrogen，and then rehydrated with water.Other soaking solutions were injected directly after filtration with membrane.The separation of target compounds was performed with an amino column BEH Amide（50 mm×21 mm，17 μm），using acetonitrile-5 mmol/L ammonium acetate as mobile phase by gradient elution.The detection on the analyte was performed with positive electrospray ionization source under multiple reaction monitoring（MRM） mode，and the quantitation was carried out by external standard method.Under the optimized conditions，the calibration curves were linear in the range of 10-7500 μg/L，with correlation coefficients larger than 0997.The limits of detection（LODs，S/N=3） and quantitation（LOQs，S/N=10） were in the ranges of 03-50 μg/kg and 10-150 μg/kg，respectively.The average recoveries for 5 ethanolamine compounds at the spiked levels of 10-7500 μg/kg were in the range of 902%-118%，with relative standard deviations of 05%-88%.The method is sensitive and accurate，and could meet the requirements for correlative determination.