A surface enhanced Raman spectroscopy（SERS） combined with chemometrics algorithms was established for the quantitative detection of aspartame（APM） in soft drinks based on the application of ultrasonography.The sample was detected using nano silver as active substrate,with a nano silver to APM ratio of 1∶1 at pH 5.0,a mixing temperature of 30 ℃ and a heating time of 6 min.A quantitative analysis mode was set up by using the monadic linear regression method to analyse SERS spectra.Results showed that the calibration curves were linear in the range of 0.5-100 mg/L.The correlation coefficient was 0.993 3 and the detection limit（LOD）was 0.41 mg/L for APM standard.The correlation coefficients of standard solutions in Soda water,Sprite,Coke and Fanta ranged from 0.974 7 to 0.984 8.Furthermore,the average recoveries ranged from 88.4% to 121% with relative standard deviations less than 7%.Detection of APM in soft drinks by SERS has the advantages of fast analysis,nondestructive and low environmental pollution,which indicates that SERS technology is suitable for quantitative analysis of APM in food and has great potential of applying in the determination of chemical substances.