A method was developed for the rapid detection of 4-methylaminoantipyrine(MAA),4-aminoantipyrine(AA),4-formylaminoantipyrine(FAA) and 4-acetylaminoantipyrine(AAA) in foods of animal origin by ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) with a through type solid phase extraction.Samples were extracted with acetonitrile,then cleaned up with a PRiME HLB column,finally quantified by UPLC-MS/MS in MRM mode after gradient elution on an ACQUITY BEH C18 column with acetonitrile and 0.1% formic acid as mobile phases.Results showed that the calibration curves for four analytes were linear in the range of 0.5-50 μg/L with correlation coefficients(r) larger than 0.996.The limits of detection(LODs) and the limits of quantitation(LOQs) were 2 μg/kg and 5 μg/kg,respectively.The average recoveries at three spiked levels of 5,10 and 50 μg/kg ranged from 75.1% to 115%,with relative standard deviations(RSD) of 1.6%-7.4%.The proposed method is simple,rapid and accurate,and could be applied in the simultaneous determination of dipyrone metabolite residues in foods of animal origin.