A method based on QuEChERS coupled with high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was developed for the determination of ten fluorescent white agents(FWAs) residues in facial mask.After mixed with water，the sample was extracted with acetonitrile,then added NaCl and MgSO4,cleaned up with C18 and primary secondary amine(PSA).The extracts were centrifuged,concentrated,and diluted with acetonitrile,then analyzed by HPLC-MS/MS.Separation of the FWAs was carried out on a C18 column with 10 mmol/L ammonium acetate and acetonitrile by gradient elution.The compounds were detected in positive/negative ion mode under multi reaction monitoring(MRM) mode.The quantitation was performed by exteral standard method.Results showed that there were good linear relationships for the FWAs in a certain concentration range with correlation coefficients(r2) greater than 0.99.In positive mode,the limits of detection(S/N=3) and the limits of quantitation(S/N=10) were in the ranges of 0.05-1.0 μg/kg and 0.2-3.0 μg/kg,respectively,while in negative mode,they both were 0.1-1.0 mg/kg and 0.3-2.0 mg/kg,respectively.The average recoveries for ten FWAs ranged from 64.4% to 106% with relative standard deviations(RSDs) of 2.6%-8.5%.With the advantages of simple operation and high recovery,the method is suitable for the determination of 10 FWAs in facial mask.