A high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) with supercritical fluid carbon dioxide extraction(SFE) was established for the determination of 11 common psychotropic drugs in human hair.The sheared hair samples were extracted by SFE under optimized conditions.The concentrated extract was reconstituted to 100 μL with methanol,then analyzed by HPLC-MS/MS.Results showed that there existed good linear relationships for 11 common psychotropic drugs in the range of 2-200 ng/mL,with correlation coefficients(r2) greater than 0.999.The detection limits and the quantitation limits were in the ranges of 0.01-0.05 ng/mg and 0.03-0.10 ng/mg,respectively.Recoveries at the spiked levels of 0.05,0.20 and 0.40 ng/mg ranged from 816% to 94.8% with relative standard deviations(RSD) of 0.50%-3.4%.The method is rapid,sensitive and accurate,and could be used in simultaneous detection of 11 common psychotropic drugs in human hair.