An ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UPLC-Q Orbitrap HRMS) was established for the determination of 17 quinolones in lotions,emulsions and non wax based cream cosmetics.The samples were ultrasonically extracted with 0.1%formic acid and acetonitrile mixed solvent,purified with n hexane,and then separated with an Agilent Poroshell EC C18(4.6 mm×150 mm，2.7 μm) column.The analytes were detected in Full Scan/dd-MS2 mode,and quantified by the internal standard method.Seventeen quinolones showed good linearities in the range of 0.05-200 μg/L with their correlation coefficients(r2) larger than 0.996 0.The limits of detection and quantitation for 17 quinolones were 0.5 μg/kg and 1.0 μg/kg,respectively.Average recoveries for 17 quinolones at three spiked levels of 2，4，20 μg/kg ranged from 82.3%to 108%with relative standard deviations(RSD，n=6) of 3.5%-8.6%.The method is rapid,accurate and sensitive,and is suitable for the determination of quinolone antibiotics in cosmetics.