刘巨, 梁涛波, 许恒毅. Advances on Application of Rolling Circle Amplification-mediated Nucleic Acid Signal Amplification Strategy in Biosensors[J]. 2020, 39(12): 1556-1560.
刘巨, 梁涛波, 许恒毅. Advances on Application of Rolling Circle Amplification-mediated Nucleic Acid Signal Amplification Strategy in Biosensors[J]. 2020, 39(12): 1556-1560.DOI: doi:10.3969/j.issn.1004-4957.2020.12.019.
Rolling circle amplification(RCA) is an isothermal nucleic acid amplification technique.Due to its high efficiency and high fidelity
this technique has been widely used in biosensors.This review introduces the principle of RCA technique
the common cyclization types of RCA template and the common types of RCA
as well as the fluorescent
colorimetric and electrochemical biosensors based on RCA.The aim of this review is to provide references for the further development and application of the RCA technique in biosensors.