A method was developed for the simultaneous determination of bisphenol substances in drug and food homologous products by ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS） combined with accelerated solvent extraction(ASE） and QuEChERS.The samples were extracted at 80 ℃ via two cycles of ASE

with acetonitrile-acetic acid-water(89∶1∶10

by volume） for 6 min

then purified by QuEChERS.11 bisphenol substances were separated on an ACQUITY UPLC HSS T3 column(2.1 mm×100 mm

1.8 μm） by gradient elution using methanol containing 0.1% formic acid and 5 mmol/L ammonium acetate containing 0.1% formic acid as mobile phases

then analyzed by MS/MS with electrospray ionization in positive and negative mode under multiple reaction monitoring(MRM） mode

finally quantified by internal standard method.There were good linear relationships for 11 bisphenol substances in the concentration range of 0.5-50.0 μg/L

with correlation coefficients(r2） not less than 0.996 0.The limits of detection(LOD） and limits of quantitation(LOQ） for 11 bisphenol substances were in the ranges of 0.1-0.5 μg/kg and 0.3-1.5 μg/kg

respectively.The recoveries at three spiked levels ranged from 72.4% to 108% with relative standard deviations(RSD） of 1.7%-15%.The proposed method was simple

rapid

high sensitive and reproducible

and it was suitable for the rapid determination of 11 bisphenol substances in drug and food homologous products.