Lipidomics is a new branch of science relying on analytical techniques

which is used to fully characterize the lipid molecules related closely to gene regulation

protein expression and lipid metabolism.With the further development of mass spectrometry and its coupled technologies

lipidomics has been gradually becoming rapid

automated and high throughput.However

data processing in large scale lipidomics analysis is still highly challenging.Chemometrics is mainly used in the baseline correction and background deduction

chromatographic peak identification

isotope distribution resolving

etc.Therefore

automated data processing strategies based on chemometrics have attracted attentions from many researchers.In this paper

the chemometric methods applied in lipidomics data processing in recent years are briefly reviewed

and the future development tendency of automated data processing in lipidomics are also prospected.