A high sensitivity and throughput method was developed for the simultaneous determination of 152 pesticide residues in vegetables and fruits by gas chromatography tandem mass spectrometry(GC-MS/MS) with QuEChERS-dispersed liquid-liquid microextraction(DLLME).Pesticide residues in vegetables and fruits samples were extracted by QuEChERS method with acetonitrile.Then after centrifugation

the acetonitrile supernatant was added with trace chloroform(CHCl3) for DLLME.The extract was analyzed by(GC-MS/MS) with electron impact ion source(EI) in selective reaction monitoring mode(SRM).Results showed that there were good linear relationships for 152 pesticides including isomers in the range of 5.0-200 μg/L with correlation coefficients above 0.995.The recoveries for the analytes at low

medium and high levels were in the range of 60.6%-119%

with relative standard deviations(RSD

n=6) of 1.5%-20%.The limits of detection and the limits of quantitation were in the ranges of 0.14-2.3 μg/kg and 0.45-7.7 μg/kg

respectively.The method is simple

accurate and sensitive.It is suitable for the high throughput and rapid detection of multi residues in fresh agricultural products such as vegetables and fruits.