An ultra high performance liquid chromatography-tandem mass spectrometric(UPLC-MS/MS) method was developed for the simultaneous determination of tetrabromobisphenol A(TBBPA) and hexabromocyclododecane(HBCD) in aquatic products.Sample preparation was based on QuEChERS procedure.The target analytes in samples were extracted with acetonitrile，followed by a dispersive solid phase extraction clean up procedure using C18.Separation of TBBPA and HBCD isomers was achieved on a CORTECS- C18(4.6 mm×100 mm×2.7 μm) column with gradient elution using water-methanol as mobile phase at a flow rate of 0.7 mL/min.The MS/MS analysis was performed with electrospray ion source in negative mode under multiple reaction monitoring(MRM) mode.Good linearities for TBBPA and three HBCD isomers were achieved in the concentration range of 0.5-500 μg/L，with their correlation coefficients(r) above 0.998.The limits of detection(LOD) and the limits of quantitation(LOQ) were in the ranges of 0.04-0.16 μg/kg and 0.12-0.55 μg/kg，respectively. Recoveries at three spiked levels of 5，20 and 50 μg/kg ranged from 74.0% to 121%，with relative standard deviations(RSDs) of 0.20%-23%.The developed method was simple，rapid and reliable，and was suitable for the rapid determination of TBBPA and HBCD in aquatic products.