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1.国科大杭州高等研究院 环境学院,浙江 杭州 310024
2.中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京 100085
刘念,博士,助理研究员,研究方向:单细胞金属分析,E-mail:liunian@ucas.ac.cn
收稿日期:2025-05-27,
修回日期:2025-06-28,
纸质出版日期:2025-09-15
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袁俊豪,刘念,刘丽红,郭华,李莹莹,何滨,胡立刚.单细胞水平汞在大脑组织中的赋存规律研究进展[J].分析测试学报,2025,44(09):1754-1763.
YUAN Jun-hao,LIU Nian,LIU Li-hong,GUO Hua,LI Ying-ying,HE Bin,HU Li-gang.Research Progress in the Distribution Patterns of Mercury in Brain Tissue at the Single-cell Level[J].Journal of Instrumental Analysis,2025,44(09):1754-1763.
袁俊豪,刘念,刘丽红,郭华,李莹莹,何滨,胡立刚.单细胞水平汞在大脑组织中的赋存规律研究进展[J].分析测试学报,2025,44(09):1754-1763. DOI: 10.12452/j.fxcsxb.25052704.
YUAN Jun-hao,LIU Nian,LIU Li-hong,GUO Hua,LI Ying-ying,HE Bin,HU Li-gang.Research Progress in the Distribution Patterns of Mercury in Brain Tissue at the Single-cell Level[J].Journal of Instrumental Analysis,2025,44(09):1754-1763. DOI: 10.12452/j.fxcsxb.25052704.
汞作为全球性污染物,可在大脑组织中蓄积并产生不可逆的神经退行性病变,严重威胁人类健康。传统研究多聚焦于组织水平的汞含量和分布,掩盖了大脑细胞中汞的异质性。单细胞水平下汞在大脑组织中的赋存研究可揭示不同细胞类型及个体中汞的累积和代谢差异,解析大脑细胞对汞暴露的异质性响应,有助于深入理解汞的特异性毒性机制,为精准评估汞暴露的神经毒性风险及开发靶向干预策略提供科学依据。该文综述了单细胞水平汞在大脑组织中的赋存特征,探讨了汞的形态及暴露条件、细胞类型及状态、组织微环境等因素对单细胞汞赋存的影响;总结了单细胞金属检测技术在汞研究中的应用进展;最后,对单细胞水平汞在大脑中的研究所面临的挑战和发展方向进行了总结和展望。
Mercury(Hg),as a global pollutant,can accumulates in brain tissues and induces irreversible neurodegenerative damage,posing a severe threat to human health. Conventional studies predominantly focus on tissue-level Hg content and distribution,masking its cellular heterogeneity. Single-cell investigations into Hg distribution within brain tissues unveil cell-type-specific accumulation and metabolic variations,resolving heterogeneous cellular responses to Hg exposure. These advances deepen the understanding of Hg's neurotoxic mechanisms and provide scientific foundations for precise assessment of neurotoxic risks and development of targeted intervention strategies. This review summarizes the characteristics of single-cell Hg distribution in brain tissues,and discusses key determinants including Hg speciation,exposure conditions,cellular phenotypes,functional states,and tissue microenvironment. We further summarize advancements in single-cell metal detection technologies for Hg analysis and critically address current challenges and future directions in this emerging field.
Jonsson S , Mastromonaco M N , Wang F , Bravo A G , Cairns W R L , Chetelat J , Douglas T A , Lescord G , Ukonmaanaho L , Heimburger-Boavida L E . Sci. Total Environ. , 2022 , 850 : 157445 .
Yin X , Zhou W , Su Y , Tang C , Guo J , Liu Z , Wang Y , Zhang X , Rupakheti D , Kang S . Sci. Total Environ. , 2024 , 954 : 176652 .
Chu Z , Zhou Y , Liu M , Lin H , Cheng M , Xie H , Yuan L , Zhang Z , Zhang Q , Li C , Chen Y , Guo Y , Chen L , Wang X . Environ. Sci. Technol. , 2023 , 57 ( 45 ): 17278 - 17290 .
Espejo W , Celis J E , O'Driscoll N J , Sandoval M . Mar. Pollut. Bull. , 2024 , 209 : 117239 .
Souza J S , Kasper D , da Cunha L S T , Soares T A , de Lira Pessoa A R , de Carvalho G O , Costa E S , Niedzielski P , Torres J P M . Chemosphere , 2020 , 261 : 127713 .
Romero-Romero S , García-Ordiales E , Roqueñí N , Acuña J L . Chemosphere , 2022 , 292 : 133445 .
Driscoll C T , Mason R P , Chan H M , Jacob D J , Pirrone N . Environ. Sci. Technol. , 2013 , 47 ( 10 ): 4967 - 4983 .
World Health Organization . Guidelines for Drinking-water Quality:Fourth Edition Incorporating the First and Second Addenda . Geneva : World Health Organization , 2022 : 425 - 426 .
Wells E M , Herbstman J B , Lin Y H , Hibbeln J R , Halden R U , Witter F R , Goldman L R . Environ. Res. , 2017 , 154 : 247 - 252 .
Cambier S , Fujimura M , Bourdineaud J P . Food Chem. Toxicol. , 2018 , 122 : 11 - 20 .
Xu X H , Han J L , Abeysinghe K S , Atapattu A J , De Silva P M C S , Xu Z D , Long S T , Qiu G L . Chemosphere , 2020 , 239 : 124749 .
Bjorklund G , Dadar M , Mutter J , Aaseth J . Environ. Res. , 2017 , 159 : 545 - 554 .
Rodrigues J L , Serpeloni J M , Batista B L , Souza S S , Jr Barbosa F . Arch. Toxicol. , 2010 , 84 ( 11 ): 891 - 896 .
Landrigan P J , Sonawane B , Butler R N , Trasande L , Callan R , Droller D . Environ. Health Perspect. , 2005 , 113 ( 9 ): 1230 - 1233 .
Petersen M S , Halling J , Bech S , Wermuth L , Weihe P , Nielsen F , Jørgensen P J , Budtz-Jørgensen E , Grandjean P . NeuroToxicology , 2008 , 29 ( 4 ): 584 - 590 .
Sakamoto M , Kakita A , Domingo J L , Yamazaki H , Oliveira R B , Sarrazin S L , Eto K , Murata K . Environ. Res. , 2017 , 152 : 446 - 453 .
Neely M D , Xie S , Prince L M , Kim H , Tukker A M , Aschner M , Thimmapuram J , Bowman A B . Food Chem. Toxicol. , 2021 , 154 : 112288 .
Zagare A , Balaur I , Rougny A , Saraiva C , Gobin M , Monzel A S , Ghosh S , Satagopam V P , Schwamborn J C . NPJ Parkinson's Dis. , 2025 , 11 ( 1 ): 63 .
Garcia F J , Sun N , Lee H , Godlewski B , Mathys H , Galani K , Zhou B , Jiang X , Ng A P , Mantero J , Tsai L H , Bennett D A , Sahin M , Kellis M , Heiman M . Nature , 2022 , 603 ( 7903 ): 893 - 899 .
Han L , Liu Z , Jing Z , Liu Y , Peng Y , Chang H , Lei J , Wang K , Xu Y , Liu W , Wu Z , Li Q , Shi X , Zheng M , Wang H , Deng J , Zhong Y , Pan H , Lin J , Zhang R , Chen Y , Wu J , Xu M , Ren B , Cheng M , Yu Q , Song X , Lu Y , Tang Y , Yuan N , Sun S , An Y , Ding W , Sun X , Wei Y , Zhang S , Dou Y , Zhao Y , Han L , Zhu Q , Xu J , Wang S , Wang D , Bai Y , Liang Y , Liu Y , Chen M , Xie C , Bo B , Li M , Zhang X , Ting W , Chen Z , Fang J , Li S , Jiang Y , Tan X , Zuo G , Xie Y , Li H , Tao Q , Li Y , Liu J , Liu Y , Hao M , Wang J , Wen H , Liu J , Yan Y , Zhang H , Sheng Y , Yu S , Liao X , Jiang X , Wang G , Liu H , Wang C , Feng N , Liu X , Ma K , Xu X , Han T , Cao H , Zheng H , Chen Y , Lu H , Yu Z , Zhang J , Wang B , Wang Z , Xie Q , Pan S , Liu C , Xu C , Cui L , Li Y , Liu S , Liao S , Chen A , Wu Q F , Wang J , Liu Z , Sun Y , Mulder J , Yang H , Wang X , Li C , Yao J , Xu X , Liu L , Shen Z , Wei W , Sun Y G . Neuron , 2025 , 113 : 1 - 20 .
Tepper K , King J , Manuneedhi Cholan P , Pfitzner C , Morsch M , Apte S C , Maselko M . Nat. Commun. , 2025 , 16 ( 1 ): 1117 .
Evans R D , Addison E M , Villeneuve J Y , MacDonald K S , Joachim D G . Environ. Res. , 2000 , 84 ( 2 ): 133 - 139 .
Garnero P L , Monferran M V , Bistoni M D I Á . Aquat. Toxicol. , 2020 , 226 : 105567 .
Antunes dos Santos A , Appel Hort M , Culbreth M , López-Granero C , Farina M , Rocha J B T , Aschner M . J . Trace Elem. Med. Biol. , 2016 , 38 : 99 - 107 .
Moneim A E . Neural Regen . Res. , 2015 , 10 ( 6 ): 881 - 882 .
Rooney J P K . Toxicol. Appl. Pharmacol. , 2014 , 274 ( 3 ): 425 - 435 .
Krey A , Kwan M , Chan H M . Environ. Res. , 2012 , 114 : 24 - 30 .
Aschner M , Syversen T . Ther. Drug Monit. , 2005 , 27 ( 3 ): 278 - 283 .
Branco V , Aschner M , Carvalho C . Neurotoxicity of Metals:Old Issues and New Developments . New York : Academic Press , 2021 : 239 - 262 .
Warfvinge K. Int . J. Exp . Pathol. , 1995 , 76 ( 1 ): 29 - 35 .
Rooney J P K . Toxicology , 2007 , 234 ( 3 ): 145 - 156 .
Aragão W A B , Teixeira F B , Fagundes N C F , Fernandes R M , Fernandes L M P , da Silva M C F , Amado L L , Sagica F E S , Oliveira E H C , Crespo-Lopez M E , Maia C S F , Lima R R . Oxid . Med. Cell. Longev. , 2018 , 2018 ( 1 ): 7878050 .
Teixeira F , Fernandes R , Farias-Junior P , Costa N , Fernandes L , Santana L , Silva-Junior A , Silva M , Maia C , Lima R . Int. J. Environ. Res. Public Health , 2014 , 11 ( 9 ): 9171 - 9185 .
Hu G Q , Jin M H , Lin X L , Guo C X , Zhang L , Sun Z W . Environ. Toxicol. Pharmacol. , 2010 , 29 ( 1 ): 7 - 11 .
Sun X M , Yu Y , Qian K , Wang J Y , Huang L . Small Methods , 2024 , 8 ( 3 ): e2301317 .
Tian X W , Wang Y , Xu T , Guo Y Y , Bi Y H , Liu Y Q , Liang Y , Cui W B , Liu Y W , Hu L G , Yin Y G , Cai Y , Jiang G B . Environ. Sci. Technol. , 2024 , 58 ( 18 ): 7860 - 7869 .
Liu S , Tsui M T-K , Lee E , Fowler J , Jia Z . Sci. Rep. , 2020 , 10 ( 1 ): 9023 .
Zhang L , Kang-Yun C S , Lu X , Chang J , Liang X , Pierce E M , Semrau J D , Gu B . Environ. Pollut. , 2023 , 331 : 121790 .
Tada Y , Marumoto K . J. Oceanogr. , 2019 , 76 ( 1 ): 63 - 70 .
Tang W , He M , Chen B , Ruan G , Xia Y , Xu P , Song G , Bi Y , Hu B . Sci. Total Environ. , 2023 , 858 ( Pt 2 ): 159894 .
Shi J , Ji X , Wu Q , Liu H , Qu G , Yin Y , Hu L , Jiang G . Anal. Chem. , 2019 , 92 ( 1 ): 622 - 627 .
Pamphlett R . Sci. Rep. , 2021 , 11 ( 1 ): 16714 .
Yao Z , van Velthoven C T J , Kunst M , Zhang M , McMillen D , Lee C , Jung W , Goldy J , Abdelhak A , Aitken M , Baker K , Baker P , Barkan E , Bertagnolli D , Bhandiwad A , Bielstein C , Bishwakarma P , Campos J , Carey D , Casper T , Chakka A B , Chakrabarty R , Chavan S , Chen M , Clark M , Close J , Crichton K , Daniel S , Di Valentin P , Dolbeare T , Ellingwood L , Fiabane E , Fliss T , Gee J , Gerstenberger J , Glandon A , Gloe J , Gould J , Gray J , Guilford N , Guzman J , Hirschstein D , Ho W , Hooper M , Huang M , Hupp M , Jin K , Kroll M , Lathia K , Leon A , Li S , Long B , Madigan Z , Malloy J , Malone J , Maltzer Z , Martin N , McCue R , McGinty R , Mei N , Melchor J , Meyerdierks E , Mollenkopf T , Moonsman S , Nguyen T N , Otto S , Pham T , Rimorin C , Ruiz A , Sanchez R , Sawyer L , Shapovalova N , Shepard N , Slaughterbeck C , Sulc J , Tieu M , Torkelson A , Tung H , Valera Cuevas N , Vance S , Wadhwani K , Ward K , Levi B , Farrell C , Young R , Staats B , Wang M M , Thompson C L , Mufti S , Pagan C M , Kruse L , Dee N , Sunkin S M , Esposito L , Hawrylycz M J , Waters J , Ng L , Smith K , Tasic B , Zhuang X , Zeng H . Nature , 2023 , 624 ( 7991 ): 317 - 332 .
Millet R T , Santos J P , Slaveykova V I . Aquat. Toxicol. , 2024 , 267 : 106836 .
Hargreaves R J , Foster J R , Pelling D , Moorhouse S R , Gangolli S D , Rowland I R . Neuropathol. Appl. Neurobiol. , 1985 , 11 ( 5 ): 383 - 401 .
Sousa A H , Pereira J P G , Malaquias A C , Sagica F , de Oliveira E H C . J. Biochem. Mol. Toxicol. , 2022 , 36 ( 10 ): e23170 .
Prince L M , Aschner M , Bowman A B . Biochim . Biophys. Acta Gen. Subj. , 2019 , 1863 ( 12 ): 129300 .
Chen X , Huang Y , Huang L , Huang Z , Hao Z Z , Xu L , Xu N , Li Z , Mou Y , Ye M , You R , Zhang X , Liu S , Miao Z . Nat. Med. , 2024 , 30 ( 9 ): 2679 - 2691 .
Leal-Nazaré C G , Arrifano G P , Lopes-Araújo A , Santos-Sacramento L , Barthelemy J L , Soares-Silva I , Crespo-Lopez M E , Augusto-Oliveira M . Sci. Total Environ. , 2024 , 920 : 170939 .
Granitzer S , Ellinger I , Khan R , Gelles K , Widhalm R , Hengstschlager M , Zeisler H , Desoye G , Tupova L , Ceckova M , Salzer H , Gundacker C . Arch. Toxicol. , 2020 , 94 ( 11 ): 3799 - 3817 .
Bridges C C , Zalups R K . Arch. Toxicol. , 2017 , 91 ( 1 ): 63 - 81 .
Yoshida E , Aoki K , Sasaki Y , Izuhara H , Takahashi T , Fujiwara Y , Fujie T , Du K , Eto K , Shinoda Y , Kaji T . J. Toxicol. Sci. , 2024 , 49 ( 5 ): 241 - 248 .
Kusuhara H , Sugiyama Y . NeuroRX , 2005 , 2 ( 1 ): 73 - 85 .
Kumar K K , Lowe E W , Aboud A A , Neely M D , Redha R , Bauer J A , Odak M , Weaver C D , Meiler J , Aschner M , Bowman A B . Sci. Rep. , 2014 , 4 ( 1 ): 6801 .
Li B , Jin X , Chan H M . Arch. Toxicol. , 2023 , 97 ( 10 ): 2625 - 2641 .
Uroz M , Wistorf S , Serra-Picamal X , Conte V , Sales-Pardo M , Roca-Cusachs P , Guimerà R , Trepat X . Nat. Cell Biol. , 2018 , 20 ( 6 ): 646 - 654 .
Vogel D G , Rabinovitch P S , Mottet N K . Cell Tissue Kinet. , 1986 , 19 ( 2 ): 227 - 242 .
Hu G Q . MeHg-induced Brain Developmental Injury and Related Cell Cycle Negative Regulation Mediated by PKC and CaN . Changchun : Jilin University(胡桂芹. 甲基汞致脑发育损伤及PKC和CaN介导的细胞周期负向调控. 长春:吉林大学) , 2010 .
Lai Y , Gao F F , Ge R T , Liu R , Ma S , Liu X . Cell Biol. Toxicol. , 2024 , 40 ( 1 ): 72 .
Tinggi U , Perkins A V . Nutrients , 2022 , 14 ( 24 ): 5308 .
Fernandez-Bautista T , Gomez-Gomez B , Vicente-Zurdo D , Madrid Y . Anal. Bioanal. Chem. , 2024 , 416 ( 11 ): 2749 - 2759 .
Liu J H , Cui J S , Wei X , Li W T , Liu C R , Li X W , Chen M L , Fan Y , Wang J H . Anal. Chim. Acta , 2021 , 1182 : 338941 .
Yao C P , Allen J W , Aschner M . Ann. N. Y. Acad. Sci. , 2006 , 890 ( 1 ): 223 - 226 .
Korbas M , Blechinger S R , Krone P H , Pickering I J , George G N . Proc. Natl. Acad. Sci. USA , 2008 , 105 ( 34 ): 12108 - 12112 .
Ni M , Li X , Yin Z , Sidoryk-Wegrzynowicz M , Jiang H , Farina M , Rocha J B , Syversen T , Aschner M . Glia , 2011 , 59 ( 5 ): 810 - 820 .
Pardhe B D , Lee M J , Lee J H , Do H , Oh T J . Sci. Rep. , 2023 , 13 ( 1 ): 17854 .
Yang R , Roshani D , Gao B , Li P , Shang N . Antioxidants , 2024 , 13 ( 7 ): 825 .
Bridges C C , Zalups R K . J. Toxicol. Environ. Health B , 2010 , 13 ( 5 ): 385 - 410 .
Aschner M , Conklin D R , Yao C P , Allen J W , Tan K H . Brain Res. , 1998 , 813 ( 2 ): 254 - 261 .
Vitarella D , Conklin D R , Kimelberg H K , Aschner M . Brain Res. , 1996 , 738 ( 2 ): 213 - 221 .
Duan C , Wang H , Jiao D , Geng Y , Wu Q , Yan H , Li C . Front. Pharmacol. , 2022 , 13 : 889226 .
Van Acker T , Theiner S , Bolea-Fernandez E , Vanhaecke F , Koellensperger G . Nat. Rev. Methods Primers , 2023 , 3 ( 1 ): 52 .
Tian X , Li X , Liu N , Cui W , Zheng L , Guo Y , Liu Y , Hu L , Wang M , Liang Y , Yin Y , Cai Y , Jiang G , Jin L . Chem. Commun. , 2023 , 59 ( 38 ): 5709 - 5712 .
Qin W , Stark H J , Muller S , Reemtsma T . Front. Microbiol. , 2022 , 13 : 870931 .
Zhang T , Warden A R , Li Y , Ding X . Clin. Transl. Med. , 2020 , 10 ( 6 ): e206 .
Liu N , Chen H G , Li Y , Zhang G , Zhang J , Qu G , He B , Meng T Q , Xiong C L , Pan A , Yin Y , Liang Y , Shi J , Wang Y X , Hu L , Jiang G . Environ. Sci. Technol. , 2023 , 57 ( 19 ): 7358 - 7369 .
Ping X N . Adv. Anal. Chem. (平欣妮. 分析化学进展), 2023 , 13 ( 2 ): 97 - 104 .
Kim H N , Ren W X , Kim J S , Yoon J . Chem. Soc. Rev. , 2012 , 41 ( 8 ): 3210 - 3244 .
Chen X , Baek K H , Kim Y , Kim S J , Shin I , Yoon J . Tetrahedron , 2010 , 66 ( 23 ): 4016 - 4021 .
Yuan B , Wang D X , Zhu L N , Lan Y L , Cheng M , Zhang L M , Chu J Q , Li X Z , Kong D M . Chem. Sci. , 2019 , 10 ( 15 ): 4220 - 4226 .
Oh S , Jeon J , Jeong J , Park J , Oh E T , Park H J , Lee K H . Anal. Chem. , 2020 , 92 ( 7 ): 4917 - 4925 .
Danscher G , Schrøder H D . Histochemistry , 1979 , 60 ( 1 ): 1 - 7 .
Thomen A , Najafinobar N , Penen F , Kay E , Upadhyay P P , Li X , Phan N T N , Malmberg P , Klarqvist M , Andersson S , Kurczy M E , Ewing A G . ACS Nano , 2020 , 14 ( 4 ): 4316 - 4325 .
Jiang H , Kilburn M R , Decelle J , Musat N . Curr. Opin. Biotechnol. , 2016 , 41 : 130 - 135 .
Malherbe J , Penen F , Isaure M P , Frank J , Hause G , Dobritzsch D , Gontier E , Horreard F , Hillion F , Schaumloffel D . Anal. Chem. , 2016 , 88 ( 14 ): 7130 - 7136 .
Meng Y , Cheng X , Wang T , Hang W , Li X , Nie W , Liu R , Lin Z , Hang L , Yin Z , Zhang B , Yan X . Angew. Chem. Int. Ed. , 2020 , 59 ( 41 ): 17864 - 17871 .
Malucelli E , Procopio A , Fratini M , Gianoncelli A , Notargiacomo A , Merolle L , Sargenti A , Castiglioni S , Cappadone C , Farruggia G , Lombardo M , Lagomarsino S , Maier J A , Iotti S . Anal. Bioanal. Chem. , 2017 , 410 ( 2 ): 337 - 348 .
Hare D J , Lee J K , Beavis A D , van Gramberg A , George J , Adlard P A , Finkelstein D I , Doble P A . Anal. Chem. , 2012 , 84 ( 9 ): 3990 - 3997 .
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