Surveillance and Ecological Risk Evaluation of Common Antibiotics in Key Discharge Points Along the Wei River，Guanzhong Basin

ZHANG Qin-ming; JIANG Xian-zhi; ZHANG Chun; ZHANG Ying; WU Wei-dong; BAI Lu; MENG Ling-jie

doi:10.12452/j.fxcsxb.241126556

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Surveillance and Ecological Risk Evaluation of Common Antibiotics in Key Discharge Points Along the Wei River，Guanzhong Basin

Scientific Papers | 更新时间：2025-08-08

- Surveillance and Ecological Risk Evaluation of Common Antibiotics in Key Discharge Points Along the Wei River，Guanzhong Basin
- Journal of Instrumental Analysis Vol. 44, Issue 8, Pages: 1620-1630(2025)
- 作者机构：
  
  1.陕西省环境监测中心站，陕西省环境介质痕量污染物监测预警重点实验室，陕西西安 710018
  2.西安交通大学大型仪器设备共享实验中心，陕西西安 710049
  3.西安交通大学化学学院，陕西西安 710049
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.241126556
  CLC： O657.7;X132
- Received：26 November 2024，
  
  Revised：07 January 2025，
  
  Accepted：07 January 2025，
  
  Published：15 August 2025
- 稿件说明：
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张秦铭,姜显智,张淳,张莹,吴卫东,白璐,孟令杰.关中地区渭河主要排污口常见抗生素监测与生态风险研究[J].分析测试学报,2025,44(08):1620-1630.

ZHANG Qin-ming,JIANG Xian-zhi,ZHANG Chun,ZHANG Ying,WU Wei-dong,BAI Lu,MENG Ling-jie.Surveillance and Ecological Risk Evaluation of Common Antibiotics in Key Discharge Points Along the Wei River，Guanzhong Basin[J].Journal of Instrumental Analysis,2025,44(08):1620-1630.
张秦铭,姜显智,张淳,张莹,吴卫东,白璐,孟令杰.关中地区渭河主要排污口常见抗生素监测与生态风险研究[J].分析测试学报,2025,44(08):1620-1630. DOI： 10.12452/j.fxcsxb.241126556.

ZHANG Qin-ming,JIANG Xian-zhi,ZHANG Chun,ZHANG Ying,WU Wei-dong,BAI Lu,MENG Ling-jie.Surveillance and Ecological Risk Evaluation of Common Antibiotics in Key Discharge Points Along the Wei River，Guanzhong Basin[J].Journal of Instrumental Analysis,2025,44(08):1620-1630. DOI： 10.12452/j.fxcsxb.241126556.

摘要

建立了检测污水中常见抗生素的在线固相萃取/液相色谱-串联质谱方法。通过运用同位素内标法，实现了7类42种常见抗生素的自动化处理与定量检测，线性范围为1~500 ng/L，相关系数（

²）大于0.97。采用所建方法对渭河流域咸阳至西安段进行了深入调查。按照丰水期、平水期、枯水期的不同时段，对24个关键排污口处的42种抗生素进行了监测与风险评估，发现该河段水体中普遍检出42种抗生素，各水期的总质量浓度为5 110.3~21 378.1 ng/L，其中，1月（枯水期）浓度最高，5月（平水期）次之，9月（丰水期）则最低。克拉霉素、氧氟沙星、磺胺甲

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唑不仅检出频次高，且浓度较高，成为该区域的主要抗生素污染源。通过风险商值法评估发现，氧氟沙星、罗红霉素、磺胺甲

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唑在多个监测点达到高生态风险等级，需引起高度重视。该研究不仅为地表水及污水中抗生素的监测提供了一种高灵敏度、高效率的检测技术，更为深入了解渭河流域关中段的抗生素污染现状，以及制定科学有效的治理策略提供了重要依据。

Abstract

To address the challenges of complex matrix interference and cumbersome sample processing in wastewater analysis，we developed an online solid phase extraction and liquid chromatography-tandem mass spectrometry（SPE/LC-MS/MS） method. Utilizing an isotope dilution internal standard approach，this technique facilitates automated processing and single-step quantitative detection of 42 common antibiotics，with a linear range of 1-500 ng/L and

² values greater than 0.97 for most antibiotics. Using this innovative method，we conducted a comprehensive monitoring and risk assessment of 42 antibiotics at 24 key discharge points along the Wei River Basin from Xianyang to Xi'an across wet，normal，and dry water periods. Our findings revealed the presence of 42 antibiotics across six major classes，with total concentrations ranging from 5 110.3 to 21 378.1 ng/L. Clarithromycin，ofloxacin，and sulfanethoxazole emerged as significant contaminants，exhibiting high detection frequencies and concentrations. Seasonal variations in total antibiotic concentrations were noted，with the highest levels recorded in January （dry period），followed by May （normal period），and the lowest in September （wet period）. Using the risk entropy method for assessment，we identified that ofloxacin，azithromycin，and sulfanethoxazole reached high ecological risk levels at mult

iple monitoring sites. This study not only provides a highly sensitive and efficient detection method for monitoring antibiotics in surface water and wastewater but also offers a scientific basis for investigating the status of antibiotic pollution and developing effective remediation strategies in the Guanzhong section of the Wei River Basin.

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